Trisomy 21 and Risk of Retinopathy of Prematurity.

نویسندگان

  • Tammy Z Movsas
  • Alan R Spitzer
  • Ira H Gewolb
چکیده

BACKGROUND AND OBJECTIVES Trisomy 21 is known to decrease the risk of several (nonocular) angiogenic-mediated diseases. The objective of this study was to determine whether trisomy 21 can also be shown to be significantly protective against ocular angiogenic-mediated disorders such as retinopathy of prematurity (ROP). METHODS A retrospective analysis of deidentified data from the Pediatrix BabySteps Clinical Warehouse. This large repository of neonatal data is approved for use in research studies by the Western Institutional Review Board. The study population consisted of 99,080 infants with very low birth weights (BWs; BW <1500 g), born between 1996 and 2013, cared for at >300 US NICUs, and who had been discharged alive from hospital. Statistical significance for unadjusted comparisons between groups was determined with Pearson's χ(2) test or Student's t test. Logistic regression models were used to calculate the odds of ROP (of any stage) and advanced ROP (stage 3 or greater) for infants with trisomy 21 compared with all other infants. RESULTS The prevalence of trisomy 21 was 0.3% in the study population (321 of 99,080). After adjustment for BW, gestational age, oxygen exposure, and other potential confounders, there was an odds ratio of 0.6 (95% confidence interval: 0.5-0.8) for ROP in infants with trisomy 21compared with other infants and an odds ratio of 0.4 (95% confidence interval: 0.1-0.9) for advanced-stage ROP. CONCLUSIONS Trisomy 21 significantly decreases the odds for ROP in very low BW infant survivors. This study unmasks a potentially identifiable genetic component to ROP risk, paving the way for the development of a laboratory-based ROP screening tool.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Incidence Rate of Retinopathy of Prematurity and Related Risk Factors: a Study on premature neonates hospitalized in two hospitals in Sari, Iran, 2014-2015

Background & Aims: Retinopathy OF prematurity (ROP) is a developmental disorder of retinal vessels in premature neonates. In recent years, because of advances in the care of neonates hospitalized in equipped Intensive care units, retinopathy of prematurity has become a major cause of blindness in those who are survived. This study assessed the incidence and severity of retinopathy and related r...

متن کامل

Frequency and Risk Factors of Retinopathy of Prematurity in Newborns Admitted to Neonatal Intensive Care Unit in Hamadan

Background and Objective: Retinopathy of prematurity (ROP) is an evolutionary disorder in the retina of premature infants. Nowadays, the prevalence rate of retinopathy has increased due to the advancement of medical facilities and the increased survival of preterm infants. The aim of this study was to determine the prevalence rate of ROP and its related risk factors among infants admitted to an...

متن کامل

Evaluation of Risk Factors for Retinopathy of Prematurity in Preterm Neonates

Background: The most common cause of preventable blindness in children is retinopathy of prematurity (ROP). The most important risk factors for this disease are preterm delivery and low birth weight (LBW). This research was performed to evaluate the prevalence ofand risk factors for ROP in preterm neonates. Methods: Our research was a cross-sectional descriptive and retrospective study conduct...

متن کامل

Prevalence and related factors of retinopathy of prematurity (ROP) in preterm infants in ophthalmology clinic of Birjand University of Medical Science from 2014 to 2016

Introduction: The prevalence of retinopathy of prematurity is expected to increase along with the developing of premature infants’ care and better prognosis of these infants. The aim of this study was to evaluate the prevalence of retinopathy of prematurity in preterm infants. Methods: According to this cross-sectional study, one same ophthalmologist examined the eyes of all the babies at 4 we...

متن کامل

Incidence of Retinopathy of Prematurity (ROP) in Low Birth Weight Newborns

Background: Retinopathy of prematurity (ROP) is a common cause of blindness and accounts for up to 10% of childhood blindness in developed countries. Also Before surfactant became available in the NICU, an incidence of 11% to 60% was reported in the VLBW population. However, there are few studies on the incidence of ROP among low-birth-weight (LBW) infants in Iran and the aim of this study is d...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Pediatrics

دوره 136 2  شماره 

صفحات  -

تاریخ انتشار 2015